3-hydroxyhexanoylcarnitine (1) to hexanoylglutamine

Numerator Metabolite

Structure of 3-hydroxyhexanoylcarnitine (1)
Metabolite Accession: GCST90200228
Name: 3-hydroxyhexanoylcarnitine (1)
Hmdb Id: HMDB0013131
Super Pathway: NA
Sub Pathway: NA
Inchikey: VYEONLJQPYRKAN

Denominator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Associated Genomic Regions

Region: rs77773255

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.407
Position:
76217193
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
25.182
Reference Allele:
G
-log10(P):
-320.511
MAF:
0.307
Beta (Num):
0.122
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.285
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid metabolism (acyl glutamine)3[1], 4[2]

Ratio Explanation:

Reduced ACADM activity leads to the accumulation of its substrate, hexanoyl-CoA, which is then shunted into detoxification pathways, forming both 3-hydroxyhexanoylcarnitine and hexanoylglutamine.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM function impairs fatty acid oxidation, a key energy source, which can impact systemic energy balance and development, reflected in traits like body weight, height, and various hematological and serum biomarkers.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data