glutamine conjugate of c7h12o2* to n-acetylglycine

Numerator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of n-acetylglycine
Metabolite Accession: GCST90199688
Name: n-acetylglycine
Hmdb Id: HMDB0000532
Super Pathway: NA
Sub Pathway: NA
Inchikey: OKJIRPAQVSHGFK

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.189
Position:
76192508
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
9.473
Reference Allele:
G
-log10(P):
-47.353
MAF:
0.338
Beta (Num):
0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, xenobiotic conjugation.5[1]

Denominator Metabolite Explanation:

Amino acid metabolism, glycine conjugation.6[1], 7[2]

Ratio Explanation:

Reduced ACADM function likely impairs fatty acid oxidation, leading to accumulation and subsequent glutamine conjugation of medium-chain fatty acids like C7H12O2.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype was provided. Defective ACADM causes impaired fatty acid oxidation, reflected by the altered ratio, which can lead to metabolic crises like hypoketotic hypoglycemia.8[1], 9[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data