nonanoylcarnitine (c9) to laurylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90200031

Name: nonanoylcarnitine (c9)

Hmdb Id: HMDB0013288

Super Pathway: NA

Sub Pathway: NA

Inchikey: MPSPNFAQQQMFLK

Denominator Metabolite

Metabolite Accession: GCST90199750

Name: laurylcarnitine (c12)

Hmdb Id: HMDB000225

Super Pathway: NA

Sub Pathway: NA

Inchikey: FUJLYHJROOYKRA

Associated Genomic Regions

Region: rs7534754

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

-0.333

Position:

76185308

SE (Ratio):

0.013

Effect Allele:

Z-score (Ratio):

-26.490

Reference Allele:

-log10(P):

-354.354

MAF:

0.302

Beta (Num):

-0.377

Novel Locus:

SE (Num):

0.016

Beta (Den):

-0.044

SE (Den):

0.016

No CNV overlap

rQTL cluster:

161

Reaction Distance:

Closest Genes:

ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4^[1], 5^[2], 6^[3], 7^[4]

Denominator Metabolite Explanation:

Fatty acid metabolism/oxidation.5^[1], 6^[2], 8^[3]

Ratio Explanation:

An elevated nonanoylcarnitine (C9) to laurylcarnitine (C12) ratio suggests decreased MCAD enzyme efficiency, as both are medium-chain acylcarnitines metabolized by this enzyme.1^[1], 9^[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data