3-hydroxybutyrate to 3-hydroxybutyroylglycine**

Numerator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Denominator Metabolite

Metabolite Accession: GCST90200174
Name: 3-hydroxybutyroylglycine**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7541058

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.183
Position:
76199817
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-11.763
Reference Allele:
C
-log10(P):
-71.884
MAF:
0.337
Beta (Num):
-0.028
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.155
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Ketogenesis, Fatty acid beta-oxidation.6[1]

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine).7[1]

Ratio Explanation:

A higher ratio may indicate impaired ACADM activity, leading to increased 3-hydroxybutyrate from fatty acid oxidation and its subsequent conjugation to form 3-hydroxybutyroylglycine.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data