3-hydroxyhexanoylcarnitine (1) to 3-hydroxydecanoate

Numerator Metabolite

Structure of 3-hydroxyhexanoylcarnitine (1)
Metabolite Accession: GCST90200228
Name: 3-hydroxyhexanoylcarnitine (1)
Hmdb Id: HMDB0013131
Super Pathway: NA
Sub Pathway: NA
Inchikey: VYEONLJQPYRKAN

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs7544117

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.162
Position:
76158246
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
10.176
Reference Allele:
A
-log10(P):
-54.332
MAF:
0.336
Beta (Num):
0.121
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.041
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM SLC44A5 RABGGTB MSH4 ASB17

Region: rs2337685

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.256
Position:
151923919
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
15.800
Reference Allele:
C
-log10(P):
-127.805
MAF:
0.315
Beta (Num):
0.050
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.206
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation4[1]

Ratio Explanation:

Reduced ACADM activity can lead to the accumulation of upstream metabolites like 3-hydroxydecanoate and potentially alter levels of downstream products like 3-hydroxyhexanoylcarnitine.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data