sebacate (c10-dc) to 3-hydroxybutyroylglycine**

Numerator Metabolite

Structure of sebacate (c10-dc)
Metabolite Accession: GCST90199718
Name: sebacate (c10-dc)
Hmdb Id: HMDB0000792
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXMXRPHRNRROMY

Denominator Metabolite

Metabolite Accession: GCST90200174
Name: 3-hydroxybutyroylglycine**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4949674

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.235
Position:
76213715
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-12.073
Reference Allele:
C
-log10(P):
-75.605
MAF:
0.308
Beta (Num):
-0.079
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.156
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Omega-oxidation, Fatty acid metabolism

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine)

Ratio Explanation:

Reduced ACADM activity can lead to increased sebacate from omega-oxidation of accumulated medium-chain fatty acids and potentially impact levels of downstream acyl-glycine conjugates.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced ACADM function, as suggested by the genetic data, likely impairs mitochondrial beta-oxidation, leading to increased omega-oxidation and the formation of sebacate. The relationship to 3-hydroxybutyroylglycine is less direct but may reflect overall disturbances in fatty acid metabolism. No phenotype link was provided.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data