palmitoleoylcarnitine (c16:1)* to octanoylcarnitine (c8)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of octanoylcarnitine (c8)
Metabolite Accession: GCST90199720
Name: octanoylcarnitine (c8)
Hmdb Id: HMDB0000791
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXTATJFJDMJMIY

Associated Genomic Regions

Region: rs61797339

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.377
Position:
76189946
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
29.310
Reference Allele:
G
-log10(P):
-433.134
MAF:
0.308
Beta (Num):
-0.012
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.389
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs17843929

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
4
Beta (Ratio):
0.199
Position:
159637113
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
14.477
Reference Allele:
C
-log10(P):
-107.698
MAF:
0.264
Beta (Num):
0.009
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.191
SE (Den):
0.017
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
PPID ETFDH C4orf46 FNIP2 RXFP1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

An elevated ratio of palmitoleoylcarnitine (C16:1) to octanoylcarnitine (C8) may indicate altered fatty acid oxidation, where the downstream product (C8) is decreased relative to the upstream substrate (C16:1) due to reduced ACADM activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM activity due to genetic variants can lead to an elevated C16:1/C8 ratio, reflecting inefficient beta-oxidation of long-chain fatty acids into medium-chain fatty acids. This metabolic disruption is a key feature of inherited metabolic disorders, though no specific phenotype is linked here.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data