cis-4-decenoate (10:1n6)* to 3-hydroxybutyroylglycine**

Numerator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Denominator Metabolite

Metabolite Accession: GCST90200174
Name: 3-hydroxybutyroylglycine**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7539246

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.483
Position:
76203850
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-24.492
Reference Allele:
C
-log10(P):
-303.366
MAF:
0.307
Beta (Num):
-0.327
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.156
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism (acyl glycine).6[1], 7[2]

Ratio Explanation:

A low ratio suggests decreased ACADM function, leading to accumulation of upstream cis-4-decenoate and downstream/alternative pathway metabolite 3-hydroxybutyroylglycine.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM gene function impairs fatty acid oxidation, altering the ratio of cis-4-decenoate to 3-hydroxybutyroylglycine.1[1], 8[2] Since no phenotype is provided, a direct link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data