glutamine conjugate of c7h12o2* to octanoylcarnitine (c8)

Numerator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of octanoylcarnitine (c8)
Metabolite Accession: GCST90199720
Name: octanoylcarnitine (c8)
Hmdb Id: HMDB0000791
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXTATJFJDMJMIY

Associated Genomic Regions

Region: rs2185152

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.497
Position:
76224010
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
27.285
Reference Allele:
C
-log10(P):
-375.763
MAF:
0.310
Beta (Num):
0.107
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.391
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid conjugation, xenobiotic metabolism.

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Ratio Explanation:

This ratio reflects flux through alternative fatty acid metabolism pathways, likely due to impaired beta-oxidation from reduced ACADM enzyme function.1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM function can impair fatty acid oxidation, leading to an accumulation of medium-chain fatty acids shunted into alternative conjugation pathways, altering this ratio; no phenotype association was provided.1[1], 6[2], 7[3]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data