decanoylcarnitine (c10) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of decanoylcarnitine (c10)
Metabolite Accession: GCST90199722
Name: decanoylcarnitine (c10)
Hmdb Id: HMDB0000651
Super Pathway: NA
Sub Pathway: NA
Inchikey: LZOSYCMHQXPBFU

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs2185152

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
-0.276
Position:
76224010
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
-19.904
Reference Allele:
C
-log10(P):
-201.300
MAF:
0.308
Beta (Num):
-0.300
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.024
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid oxidation.5[1], 4[2]

Ratio Explanation:

This ratio compares a substrate of ACADM (C10) with a longer-chain acylcarnitine (C14), reflecting MCAD enzyme activity relative to long-chain fatty acid metabolism.6[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype is associated in the provided data. However, pathogenic variants in ACADM are known to cause MCAD deficiency, an inborn error of metabolism characterized by accumulation of C6-C10 acylcarnitines.1[1], 8[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data