glutamine conjugate of c7h12o2* to 3-hydroxydecanoate

Numerator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs7546641

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.151
Position:
76158035
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
9.613
Reference Allele:
T
-log10(P):
-48.704
MAF:
0.337
Beta (Num):
0.111
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.040
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM SLC44A5 RABGGTB MSH4 ASB17

Region: rs7538652

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.233
Position:
151920040
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
14.481
Reference Allele:
G
-log10(P):
-107.753
MAF:
0.317
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.207
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, dicarboxylic acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Mitochondrial fatty acid beta-oxidation.7[1], 8[2]

Ratio Explanation:

This ratio may reflect impaired ACADM-mediated beta-oxidation, leading to decreased levels of intermediates like 3-hydroxydecanoate and shunting of upstream metabolites toward alternative clearance pathways.7[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced ACADM expression, suggested by eQTL colocalization, likely impairs fatty acid oxidation.1[1], 9[2], 10[3] This could compromise energy metabolism in colonocytes, potentially weakening the intestinal wall and increasing susceptibility to diverticular disease.11[4], 12[5], 13[6] The metabolite ratio may signal this dysfunction.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data