3-hydroxyhexanoylcarnitine (1) to nonanoylcarnitine (c9)

Numerator Metabolite

Structure of 3-hydroxyhexanoylcarnitine (1)
Metabolite Accession: GCST90200228
Name: 3-hydroxyhexanoylcarnitine (1)
Hmdb Id: HMDB0013131
Super Pathway: NA
Sub Pathway: NA
Inchikey: VYEONLJQPYRKAN

Denominator Metabolite

Structure of nonanoylcarnitine (c9)
Metabolite Accession: GCST90200031
Name: nonanoylcarnitine (c9)
Hmdb Id: HMDB0013288
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPSPNFAQQQMFLK

Associated Genomic Regions

Region: rs4949674

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.501
Position:
76213715
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
25.636
Reference Allele:
C
-log10(P):
-332.069
MAF:
0.308
Beta (Num):
0.122
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.379
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2]

Ratio Explanation:

The ratio reflects fatty acid beta-oxidation efficiency; ACADM dysfunction alters the relative levels of 3-hydroxyhexanoylcarnitine and nonanoylcarnitine intermediates.9[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in ACADM regulates fatty acid oxidation, altering the ratio of 3-hydroxyhexanoylcarnitine to nonanoylcarnitine. However, no specific phenotype was associated with this dataset.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data