cis-4-decenoylcarnitine (c10:1) to (s)-3-hydroxybutyrylcarnitine

Numerator Metabolite

Structure of cis-4-decenoylcarnitine (c10:1)
Metabolite Accession: GCST90199880
Name: cis-4-decenoylcarnitine (c10:1)
Hmdb Id: HMDB0013205
Super Pathway: NA
Sub Pathway: NA
Inchikey: GOOOCIIXFLVRAG

Denominator Metabolite

Structure of (s)-3-hydroxybutyrylcarnitine
Metabolite Accession: GCST90200088
Name: (s)-3-hydroxybutyrylcarnitine
Hmdb Id: HMDB0013127
Super Pathway: NA
Sub Pathway: NA
Inchikey: UEFRDQSMQXDWTO

Associated Genomic Regions

Region: rs11161468

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.536
Position:
76192582
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-30.375
Reference Allele:
C
-log10(P):
-464.970
MAF:
0.308
Beta (Num):
-0.391
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.145
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Ketone body metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

An elevated ratio suggests impaired ACADM activity, causing accumulation of the upstream intermediate cis-4-decenoylcarnitine relative to the downstream ketone-related (s)-3-hydroxybutyrylcarnitine.8[1], 9[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in ACADM can alter the ratio of fatty acid oxidation intermediates to ketone body-related metabolites.10[1], 8[2] No associated phenotype was provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data