hexanoylglutamine to trans-2-hexenoylglycine

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of trans-2-hexenoylglycine
Metabolite Accession: GCST90200160
Name: trans-2-hexenoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: AAPHATPOQGNLOZ

Associated Genomic Regions

Region: rs77773255

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.354
Position:
76217193
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-19.716
Reference Allele:
G
-log10(P):
-197.564
MAF:
0.306
Beta (Num):
-0.285
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.069
SE (Den):
0.018
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acyl glutamine)

Denominator Metabolite Explanation:

Fatty acid metabolism (acyl glycine)

Ratio Explanation:

A decreased ratio suggests impaired ACADM activity, leading to the accumulation of upstream hexanoyl-CoA (forming hexanoylglutamine) relative to downstream glycine conjugates.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No associated phenotype was provided in the input data, so a direct link between the gene, this specific ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data