linoleate (18:2n6) to cis-4-decenoate (10:1n6)*

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Associated Genomic Regions

Region: rs61797339

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.298
Position:
76189946
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
22.740
Reference Allele:
G
-log10(P):
-261.902
MAF:
0.308
Beta (Num):
-0.029
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.327
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.427
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
32.609
Reference Allele:
G
-log10(P):
-535.380
MAF:
0.318
Beta (Num):
0.018
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.409
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis6[1], 7[2], 8[3], 9[4], Fatty acid beta-oxidation10[5], 11[6], 12[7]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation10[1], 11[2], 13[3]

Ratio Explanation:

The ratio of linoleate to cis-4-decenoate may reflect altered fatty acid beta-oxidation. Reduced ACADM activity could lead to the accumulation of its substrate, cis-4-decenoate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No direct ratio-phenotype link is provided. However, cis-4-decenoate is positively correlated with Sjögren's syndrome, an autoimmune disease. 14[1], 15[2], 16[3]ACADM deficiency is a known metabolic disorder. 1[4], 4[5], 5[6]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data