5-dodecenoylcarnitine (c12:1) to glutamine conjugate of c7h12o2*

Numerator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.198
Position:
76192508
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-11.804
Reference Allele:
G
-log10(P):
-72.364
MAF:
0.334
Beta (Num):
-0.087
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.112
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Glutamine conjugation, organic acid metabolism

Ratio Explanation:

The ratio likely reflects ACADM activity; impaired beta-oxidation increases the numerator (C12:1), while the denominator may represent an alternative metabolic or detoxification product.4[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in ACADM likely alters its enzymatic function, leading to a build-up of the numerator.6[1], 7[2] As no phenotype data is provided, a specific link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data