cis-3,4-methyleneheptanoylglycine to trans-2-hexenoylglycine

Numerator Metabolite

Metabolite Accession: GCST90200274
Name: cis-3,4-methyleneheptanoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of trans-2-hexenoylglycine
Metabolite Accession: GCST90200160
Name: trans-2-hexenoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: AAPHATPOQGNLOZ

Associated Genomic Regions

Region: rs7547056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.167
Position:
76279267
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-8.216
Reference Allele:
G
-log10(P):
-36.098
MAF:
0.266
Beta (Num):
-0.089
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.079
SE (Den):
0.018
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
MSH4 RABGGTB ACADM ASB17 SLC44A5

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Oxidation, Xenobiotic Metabolism.6[1]

Denominator Metabolite Explanation:

Fatty Acid Beta-Oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

An elevated ratio reflects impaired ACADM activity, causing accumulation and subsequent alternative glycine conjugation of upstream fatty acyl-CoA intermediates.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data