4-methylhexanoylglutamine to gamma-glutamylglycine

Numerator Metabolite

Metabolite Accession: GCST90200223
Name: 4-methylhexanoylglutamine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of gamma-glutamylglycine
Metabolite Accession: GCST90199741
Name: gamma-glutamylglycine
Hmdb Id: HMDB0011667
Super Pathway: NA
Sub Pathway: NA
Inchikey: ACIJGUBIMXQCMF

Associated Genomic Regions

Region: rs7539246

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.316
Position:
76203850
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
-12.093
Reference Allele:
C
-log10(P):
-75.841
MAF:
0.280
Beta (Num):
-0.216
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.100
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, amino acid conjugation.5[1]

Denominator Metabolite Explanation:

Glutathione metabolism, gamma-glutamyl cycle.6[1], 7[2]

Ratio Explanation:

An elevated ratio suggests impaired ACADM-mediated fatty acid oxidation, shunting acyl-CoAs to glutamine conjugation relative to normal gamma-glutamyl cycle turnover.5[1], 7[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype association was provided; therefore, a causal link between the ACADM-driven ratio and a specific phenotype cannot be established from the available data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data