4-methylhexanoylglutamine to glutamine conjugate of c7h12o2*

Numerator Metabolite

Metabolite Accession: GCST90200223
Name: 4-methylhexanoylglutamine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs6593514

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.317
Position:
76203891
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-17.298
Reference Allele:
A
-log10(P):
-152.690
MAF:
0.308
Beta (Num):
-0.207
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.110
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, amino acid conjugation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, amino acid conjugation.

Ratio Explanation:

The ratio likely reflects altered ACADM activity, causing upstream accumulation and subsequent glutamine conjugation of different medium-chain acyl-CoA precursors.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data provided; therefore, a causal link between the ACADM-driven metabolite ratio and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data