palmitoleoylcarnitine (c16:1)* to decanoylcarnitine (c10)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of decanoylcarnitine (c10)
Metabolite Accession: GCST90199722
Name: decanoylcarnitine (c10)
Hmdb Id: HMDB0000651
Super Pathway: NA
Sub Pathway: NA
Inchikey: LZOSYCMHQXPBFU

Associated Genomic Regions

Region: rs61622554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.286
Position:
76224748
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
22.381
Reference Allele:
C
-log10(P):
-253.792
MAF:
0.309
Beta (Num):
-0.013
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.300
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs17843929

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.195
Position:
159637113
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
14.319
Reference Allele:
C
-log10(P):
-105.406
MAF:
0.264
Beta (Num):
0.009
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.186
SE (Den):
0.017
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
PPID ETFDH C4orf46 FNIP2 RXFP1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

An elevated ratio of palmitoleoylcarnitine (C16:1) to decanoylcarnitine (C10) may indicate decreased ACADM enzyme efficiency, leading to the accumulation of upstream long-chain acylcarnitines.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data