3-hydroxylaurate to glutamine conjugate of c7h12o2*

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.156
Position:
76192508
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-9.684
Reference Allele:
G
-log10(P):
-49.399
MAF:
0.337
Beta (Num):
-0.044
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.112
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation, amino acid conjugation.7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

Reduced ACADM activity may increase 3-hydroxylaurate and the denominator's dicarboxylic acid precursor via beta- and omega-oxidation dysregulation, respectively.9[1], 11[2], 12[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data was provided. However, variants in ACADM are causal for Medium-chain acyl-CoA dehydrogenase deficiency (MCADD), a fatty acid oxidation disorder.11[1], 13[2], 14[3], 15[4]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data