glutamine conjugate of c6h10o2 (2)* to caprylate (8:0)

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of caprylate (8:0)
Metabolite Accession: GCST90200445
Name: caprylate (8:0)
Hmdb Id: HMDB0000482
Super Pathway: NA
Sub Pathway: NA
Inchikey: WWZKQHOCKIZLMA

Associated Genomic Regions

Region: rs7534754

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.248
Position:
76185308
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
11.333
Reference Allele:
G
-log10(P):
-66.883
MAF:
0.309
Beta (Num):
0.125
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.123
SE (Den):
0.017
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Glutamine metabolism.4[1], 5[2], 6[3], 7[4], 8[5]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.1[1], 9[2], 10[3]

Ratio Explanation:

A higher ratio suggests decreased ACADM activity, leading to reduced breakdown of caprylate (a medium-chain fatty acid) and its subsequent alternative metabolism into a glutamine conjugate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data