hexanoylglutamine to glutamine conjugate of c6h10o2 (2)*

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.400
Position:
76192508
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-30.800
Reference Allele:
G
-log10(P):
-477.977
MAF:
0.335
Beta (Num):
-0.271
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4[1]

Denominator Metabolite Explanation:

Fatty acid metabolism/oxidation.

Ratio Explanation:

This ratio reflects the efficiency of medium-chain fatty acid oxidation; impaired ACADM activity leads to the accumulation of hexanoyl-CoA, increasing its glutamine conjugate.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in ACADM impair fatty acid oxidation, altering the balance of acyl-glutamine conjugates. This disruption in systemic energy metabolism likely contributes to associated hematological phenotypes, including variations in hemoglobin and red blood cell indices observed in the BioBank Japan data.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data