glutamine conjugate of c6h10o2 (2)* to decanoylcarnitine (c10)

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of decanoylcarnitine (c10)
Metabolite Accession: GCST90199722
Name: decanoylcarnitine (c10)
Hmdb Id: HMDB0000651
Super Pathway: NA
Sub Pathway: NA
Inchikey: LZOSYCMHQXPBFU

Associated Genomic Regions

Region: rs2185152

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.423
Position:
76224010
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
23.043
Reference Allele:
C
-log10(P):
-268.848
MAF:
0.309
Beta (Num):
0.123
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.300
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, amino acid conjugation.3[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.4[1]

Ratio Explanation:

This ratio compares a detoxification product (numerator) to an accumulated substrate (denominator), likely reflecting metabolic disruption from reduced ACADM enzymatic activity.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data provided. Genetic evidence (pQTL, eQTL) and metabolite functions strongly implicate altered fatty acid metabolism due to reduced ACADM function, a hallmark of MCAD deficiency.2[1], 6[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data