3-hydroxydecanoylcarnitine to octanoylcarnitine (c8)

Numerator Metabolite

Structure of 3-hydroxydecanoylcarnitine
Metabolite Accession: GCST90200246
Name: 3-hydroxydecanoylcarnitine
Hmdb Id: HMDB0061636
Super Pathway: NA
Sub Pathway: NA
Inchikey: VCRSQDIROUELAR

Denominator Metabolite

Structure of octanoylcarnitine (c8)
Metabolite Accession: GCST90199720
Name: octanoylcarnitine (c8)
Hmdb Id: HMDB0000791
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXTATJFJDMJMIY

Associated Genomic Regions

Region: rs61622554

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.370
Position:
76224748
SE (Ratio):
0.012
Effect Allele:
T
Z-score (Ratio):
31.780
Reference Allele:
C
-log10(P):
-508.671
MAF:
0.309
Beta (Num):
-0.020
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.390
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs17843929

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.231
Position:
159637113
SE (Ratio):
0.012
Effect Allele:
T
Z-score (Ratio):
18.530
Reference Allele:
C
-log10(P):
-174.821
MAF:
0.264
Beta (Num):
0.040
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.191
SE (Den):
0.017
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
PPID ETFDH C4orf46 FNIP2 RXFP1

LLM Analysis

Numerator Metabolite Explanation:

Mitochondrial fatty acid beta-oxidation.3[1]

Denominator Metabolite Explanation:

Mitochondrial fatty acid beta-oxidation.4[1]

Ratio Explanation:

Reduced ACADM activity impairs oxidation of medium-chain fatty acids, increasing the substrate-derived octanoylcarnitine (C8) and affecting upstream intermediates like 3-hydroxydecanoylcarnitine, reflecting pathway blockage.5[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data was provided, preventing the establishment of a causal link between the ACADM-driven metabolic ratio and a clinical outcome.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data