glutamine conjugate of c6h10o2 (2)* to caproate (6:0)

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of caproate (6:0)
Metabolite Accession: GCST90200450
Name: caproate (6:0)
Hmdb Id: HMDB0000535
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUZZWVXGSFPDMH

Associated Genomic Regions

Region: rs7534754

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.310
Position:
76185308
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
13.960
Reference Allele:
G
-log10(P):
-100.304
MAF:
0.309
Beta (Num):
0.125
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.185
SE (Den):
0.017
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, amino acid conjugation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation2[1]

Ratio Explanation:

A higher ratio may indicate that caproate (or a derivative) is being redirected to glutamine conjugation due to impaired fatty acid oxidation via ACADM.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype association was provided; however, genetic deficiency in ACADM is linked to medium-chain acyl-CoA dehydrogenase deficiency (MCADD), a fatty acid oxidation disorder.4[1], 5[2], 6[3]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data