glutamine conjugate of c6h10o2 (2)* to octadecanedioate (c18-dc)

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of octadecanedioate (c18-dc)
Metabolite Accession: GCST90199805
Name: octadecanedioate (c18-dc)
Hmdb Id: HMDB0000782
Super Pathway: NA
Sub Pathway: NA
Inchikey: BNJOQKFENDDGSC

Associated Genomic Regions

Region: rs7541058

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.182
Position:
76199817
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
10.446
Reference Allele:
C
-log10(P):
-57.143
MAF:
0.337
Beta (Num):
0.128
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.054
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation, amino acid conjugation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.3[1]

Ratio Explanation:

This ratio reflects ACADM activity; impaired function increases the numerator (medium-chain dicarboxylate conjugate) relative to the denominator (long-chain dicarboxylate) due to metabolic shunting.5[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data is available; a causal link between the ACADM gene, the metabolite ratio, and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data