sebacate (c10-dc) to glutamine conjugate of c6h10o2 (2)*

Numerator Metabolite

Structure of sebacate (c10-dc)
Metabolite Accession: GCST90199718
Name: sebacate (c10-dc)
Hmdb Id: HMDB0000792
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXMXRPHRNRROMY

Denominator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12091720

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.203
Position:
76186949
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-11.262
Reference Allele:
G
-log10(P):
-66.076
MAF:
0.307
Beta (Num):
-0.078
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.125
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs56078223

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.167
Position:
151898843
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-9.027
Reference Allele:
T
-log10(P):
-43.180
MAF:
0.294
Beta (Num):
-0.101
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.066
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1]

Denominator Metabolite Explanation:

Not fully characterized, involves glutamine conjugation.5[1], 6[2], 7[3]

Ratio Explanation:

An elevated ratio suggests a shift from beta-oxidation to omega-oxidation for fatty acid metabolism, potentially due to impaired ACADM function.1[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced ACADM activity may lead to altered fatty acid metabolism. The resulting metabolic changes could contribute to the pathogenesis of diverticular disease, although the exact mechanisms are not yet established.1[1], 8[2], 4[3]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data