adipoylcarnitine (c6-dc) to (s)-3-hydroxybutyrylcarnitine

Numerator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Denominator Metabolite

Structure of (s)-3-hydroxybutyrylcarnitine
Metabolite Accession: GCST90200088
Name: (s)-3-hydroxybutyrylcarnitine
Hmdb Id: HMDB0013127
Super Pathway: NA
Sub Pathway: NA
Inchikey: UEFRDQSMQXDWTO

Associated Genomic Regions

Region: rs12132488

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.260
Position:
47389613
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-11.273
Reference Allele:
C
-log10(P):
-66.201
MAF:
0.127
Beta (Num):
-0.209
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.051
SE (Den):
0.022
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

Region: rs7524467

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.196
Position:
76194054
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-12.023
Reference Allele:
C
-log10(P):
-74.993
MAF:
0.308
Beta (Num):
-0.050
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.146
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Ketone body metabolism

Ratio Explanation:

An elevated adipoylcarnitine to (s)-3-hydroxybutyrylcarnitine ratio suggests impaired beta-oxidation due to ACADM dysfunction, shunting fatty acids toward omega-oxidation.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data