4-methylhexanoylglutamine to 3-hydroxybutyroylglycine**

Numerator Metabolite

Metabolite Accession: GCST90200223
Name: 4-methylhexanoylglutamine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200174
Name: 3-hydroxybutyroylglycine**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7539246

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.372
Position:
76203850
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-16.956
Reference Allele:
C
-log10(P):
-146.813
MAF:
0.280
Beta (Num):
-0.216
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.156
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glutamine).4[1], 5[2]

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine).5[1]

Ratio Explanation:

Reduced ACADM activity impairs fatty acid oxidation, leading to the accumulation of upstream medium-chain acyl-CoAs that are shunted to detoxification through glutamine/glycine conjugation.6[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in ACADM are strongly associated with this ratio, reflecting altered fatty acid oxidation. However, no associated phenotype was provided in the input data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data