cis-4-decenoate (10:1n6)* to dodecadienoate (12:2)*

Numerator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs61797339

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.290
Position:
76189946
SE (Ratio):
0.011
Effect Allele:
T
Z-score (Ratio):
-25.726
Reference Allele:
G
-log10(P):
-334.389
MAF:
0.306
Beta (Num):
-0.327
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.037
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs35259237

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.400
Position:
73890837
SE (Ratio):
0.046
Effect Allele:
A
Z-score (Ratio):
8.787
Reference Allele:
C
-log10(P):
-41.021
MAF:
0.013
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.065
Beta (Den):
-0.374
SE (Den):
0.064
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
NUMB HEATR4 ACOT1 ACOT2 PAPLN

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.689
Position:
74040136
SE (Ratio):
0.031
Effect Allele:
A
Z-score (Ratio):
22.196
Reference Allele:
G
-log10(P):
-249.662
MAF:
0.030
Beta (Num):
0.084
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs35779268

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.160
Position:
2300703
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-10.637
Reference Allele:
G
-log10(P):
-59.168
MAF:
0.146
Beta (Num):
-0.006
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.155
SE (Den):
0.021
No CNV overlap
rQTL cluster:
35
Reaction Distance:
NA
Closest Genes:
ECI1 RNPS1 AC009065.1 DNASE1L2 E4F1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2]

Ratio Explanation:

The ratio reflects the efficiency of the ACADM-catalyzed step in medium-chain fatty acid beta-oxidation, with defects leading to the accumulation of cis-4-decenoate.9[1], 10[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants altering ACADM function are the primary drivers of the cis-4-decenoate to dodecadienoate ratio, reflecting modified medium-chain fatty acid oxidation.9[1], 11[2] No associated phenotype was provided in the input data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data