3-hydroxybutyroylglycine** to decanoylcarnitine (c10)

Numerator Metabolite

Metabolite Accession: GCST90200174
Name: 3-hydroxybutyroylglycine**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of decanoylcarnitine (c10)
Metabolite Accession: GCST90199722
Name: decanoylcarnitine (c10)
Hmdb Id: HMDB0000651
Super Pathway: NA
Sub Pathway: NA
Inchikey: LZOSYCMHQXPBFU

Associated Genomic Regions

Region: rs7539246

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.455
Position:
76203850
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
23.291
Reference Allele:
C
-log10(P):
-274.607
MAF:
0.308
Beta (Num):
0.156
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.299
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acyl glycine).3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Ratio Explanation:

An elevated ratio suggests impaired ACADM activity, leading to the accumulation of upstream metabolites like decanoylcarnitine and alternative detoxification products like 3-hydroxybutyroylglycine.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data