hexanoylglycine to gamma-glutamylglycine

Numerator Metabolite

Metabolite Accession: GCST90199781

Name: hexanoylglycine

Hmdb Id: HMDB0000701

Super Pathway: NA

Sub Pathway: NA

Inchikey: UPCKIPHSXMXJOX

Denominator Metabolite

Metabolite Accession: GCST90199741

Name: gamma-glutamylglycine

Hmdb Id: HMDB0011667

Super Pathway: NA

Sub Pathway: NA

Inchikey: ACIJGUBIMXQCMF

Associated Genomic Regions

Region: rs7513363

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

-0.377

Position:

76143443

SE (Ratio):

0.022

Effect Allele:

Z-score (Ratio):

-16.842

Reference Allele:

-log10(P):

-144.871

MAF:

0.313

Beta (Num):

-0.281

Novel Locus:

SE (Num):

0.019

Beta (Den):

0.096

SE (Den):

0.016

No CNV overlap

rQTL cluster:

161

Reaction Distance:

Closest Genes:

ACADM SLC44A5 RABGGTB MSH4 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.2^[1], 6^[2], 7^[3]

Denominator Metabolite Explanation:

Glutathione metabolism, amino acid transport.8^[1], 9^[2]

Ratio Explanation:

Elevated hexanoylglycine results from impaired ACADM function, while gamma-glutamylglycine is involved in a separate pathway, making the ratio an indicator of disrupted fatty acid oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data