cis-4-decenoate (10:1n6)* to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs61797339

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.302
Position:
76189946
SE (Ratio):
0.011
Effect Allele:
T
Z-score (Ratio):
-26.768
Reference Allele:
G
-log10(P):
-361.768
MAF:
0.306
Beta (Num):
-0.327
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.024
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.108
Position:
74033594
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
9.840
Reference Allele:
A
-log10(P):
-50.936
MAF:
0.422
Beta (Num):
0.023
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.085
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis, Fatty acid beta-oxidation

Ratio Explanation:

A higher ratio suggests decreased ACADM activity, leading to the accumulation of cis-4-decenoate, a substrate, relative to downstream fatty acid products.5[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data