3-hydroxylaurate to glutamine conjugate of c6h10o2 (2)*

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs35630725;rs1890452

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.173
Position:
76192508
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-10.522
Reference Allele:
G
-log10(P):
-57.941
MAF:
0.337
Beta (Num):
-0.044
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs2999541

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.164
Position:
151898749
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-10.140
Reference Allele:
C
-log10(P):
-53.957
MAF:
0.374
Beta (Num):
-0.108
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.056
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid metabolism, Amino acid conjugation

Ratio Explanation:

The ratio reflects an imbalance in medium-chain fatty acid oxidation, where an ACADM functional decrease leads to the accumulation of upstream fatty acid intermediates.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM expression alters mitochondrial fatty acid oxidation. This may impair energy metabolism in the colon wall and/or promote inflammation, increasing susceptibility to the development of diverticular disease.3[1], 4[2]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data