glutamine conjugate of c6h10o2 (2)* to 3-hydroxydecanoate

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.167
Position:
76192508
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
10.664
Reference Allele:
G
-log10(P):
-59.466
MAF:
0.337
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.038
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs56078223

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.273
Position:
151898843
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
16.712
Reference Allele:
T
-log10(P):
-142.697
MAF:
0.294
Beta (Num):
0.066
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.208
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Glutamine conjugation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.3[1], 4[2]

Ratio Explanation:

An increased ratio of a C6-glutamine conjugate to 3-hydroxydecanoate likely reflects inefficient fatty acid beta-oxidation due to reduced ACADM activity, shunting intermediates toward conjugation.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM function, evidenced by the altered metabolite ratio, may impair energy metabolism in colonocytes. This dysfunction could compromise colonic wall integrity, increasing susceptibility to diverticular disease, a phenotype with known genetic underpinnings.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data