cis-3,4-methyleneheptanoylglycine to 2-butenoylglycine

Numerator Metabolite

Metabolite Accession: GCST90200274
Name: cis-3,4-methyleneheptanoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 2-butenoylglycine
Metabolite Accession: GCST90200152
Name: 2-butenoylglycine
Hmdb Id: HMDB0341232
Super Pathway: NA
Sub Pathway: NA
Inchikey: WWJXRJJBIVSSNF

Associated Genomic Regions

Region: rs11161468

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.216
Position:
76192582
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-10.988
Reference Allele:
C
-log10(P):
-62.999
MAF:
0.309
Beta (Num):
-0.088
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.018
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine)5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine)8[1], 9[2]

Ratio Explanation:

A high ratio of cis-3,4-methyleneheptanoylglycine to 2-butenoylglycine may suggest reduced ACADM enzyme activity, affecting the metabolism of their precursor acyl-CoAs in fatty acid oxidation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic evidence strongly suggests ACADM variation alters the ratio of two fatty acid-derived metabolites; however, no associated phenotype was provided in the input data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data