cis-3,4-methyleneheptanoylglycine to glutamine conjugate of c6h10o2 (2)*

Numerator Metabolite

Metabolite Accession: GCST90200274
Name: cis-3,4-methyleneheptanoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
-0.213
Position:
76192508
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-10.696
Reference Allele:
G
-log10(P):
-59.801
MAF:
0.338
Beta (Num):
-0.084
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine)5[1]

Denominator Metabolite Explanation:

Fatty Acid Metabolism, Amino Acid Conjugation6[1], 7[2]

Ratio Explanation:

The ratio likely reflects altered medium-chain fatty acid metabolism due to ACADM dysfunction, causing shunting of acyl groups to different amino acid conjugation pathways for excretion.8[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in ACADM alters its function, impacting the ratio of these fatty acid conjugates which may have downstream effects; however, no associated phenotype was provided.2[1], 10[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data