hexanoylglutamine to 2-butenoylglycine

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of 2-butenoylglycine
Metabolite Accession: GCST90200152
Name: 2-butenoylglycine
Hmdb Id: HMDB0341232
Super Pathway: NA
Sub Pathway: NA
Inchikey: WWJXRJJBIVSSNF

Associated Genomic Regions

Region: rs7524467

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.414
Position:
76194054
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-20.746
Reference Allele:
C
-log10(P):
-218.458
MAF:
0.307
Beta (Num):
-0.284
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.130
SE (Den):
0.018
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.2[1], 3[2]

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine).4[1], 5[2]

Ratio Explanation:

A higher ratio may indicate reduced ACADM enzyme function, leading to the accumulation of upstream metabolites like hexanoylglutamine and decreased levels of downstream products.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM function can lead to a buildup of medium-chain fatty acids and their derivatives, potentially causing hypoketotic hypoglycemia and other metabolic disturbances, though no specific phenotype is provided in the input data.6[1], 7[2]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data