glutamine conjugate of c6h10o2 (1)* to 5-dodecenoate (12:1n7)

Numerator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.203
Position:
76192508
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
11.300
Reference Allele:
G
-log10(P):
-66.507
MAF:
0.339
Beta (Num):
0.140
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.063
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation, amino acid conjugation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.1[1], 2[2], 3[3]

Ratio Explanation:

An increased ratio may indicate reduced ACADM activity, reflecting shunting of medium-chain fatty acids from beta-oxidation to alternative omega-oxidation and subsequent conjugation.1[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data