gamma-glutamylglycine to caprylate (8:0)

Numerator Metabolite

Structure of gamma-glutamylglycine
Metabolite Accession: GCST90199741
Name: gamma-glutamylglycine
Hmdb Id: HMDB0011667
Super Pathway: NA
Sub Pathway: NA
Inchikey: ACIJGUBIMXQCMF

Denominator Metabolite

Structure of caprylate (8:0)
Metabolite Accession: GCST90200445
Name: caprylate (8:0)
Hmdb Id: HMDB0000482
Super Pathway: NA
Sub Pathway: NA
Inchikey: WWZKQHOCKIZLMA

Associated Genomic Regions

Region: rs4949674

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.224
Position:
76213715
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
9.834
Reference Allele:
C
-log10(P):
-50.876
MAF:
0.308
Beta (Num):
0.100
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.124
SE (Den):
0.017
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Glutathione metabolism

Denominator Metabolite Explanation:

Fatty acid beta-oxidation1[1], 2[2], 4[3]

Ratio Explanation:

The ratio reflects ACADM activity. Reduced function impairs caprylate breakdown, potentially altering gamma-glutamylglycine through secondary mitochondrial stress and altered glutathione metabolism.1[1], 5[2], 6[3], 7[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype is associated, so a causal link connecting ACADM, the metabolite ratio, and a phenotype cannot be established from the available data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data