cis-4-decenoate (10:1n6)* to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs61797339

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
-0.303
Position:
76189946
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
-22.015
Reference Allele:
G
-log10(P):
-245.639
MAF:
0.306
Beta (Num):
-0.327
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.024
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
-0.428
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-31.140
Reference Allele:
G
-log10(P):
-488.526
MAF:
0.316
Beta (Num):
-0.409
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.019
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.2[1]

Denominator Metabolite Explanation:

Fatty acid metabolism.3[1], 4[2]

Ratio Explanation:

A higher ratio may indicate reduced ACADM enzyme function, leading to the accumulation of cis-4-decenoate, a metabolite of linolenate, due to impaired beta-oxidation.5[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM function, suggested by the pQTL and eQTL data, can lead to the accumulation of cis-4-decenoate from linolenate metabolism.5[1], 6[2] This is a known biomarker for MCAD deficiency, a disorder of fatty acid oxidation, but no specific phenotype is provided.7[3], 8[4]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data