glutamine conjugate of c7h12o2* to 3-hydroxymyristate

Numerator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.155
Position:
76192508
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
9.454
Reference Allele:
G
-log10(P):
-47.170
MAF:
0.338
Beta (Num):
0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.043
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Glutamine conjugation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

Reduced ACADM function can impair beta-oxidation, causing accumulation of medium-chain fatty acids that are alternatively metabolized and conjugated with glutamine, altering the ratio to 3-hydroxymyristate.1[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No definitive phenotype link was provided. However, altered ACADM function is associated with metabolic disorders, and the numerator has been linked to a reduced risk of insomnia and Parkinson's disease in other studies.3[1], 4[2], 5[3]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data