tetradecadienoate (14:2)* to octanoylcarnitine (c8)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of octanoylcarnitine (c8)
Metabolite Accession: GCST90199720
Name: octanoylcarnitine (c8)
Hmdb Id: HMDB0000791
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXTATJFJDMJMIY

Associated Genomic Regions

Region: rs12091720

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.365
Position:
76186949
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
26.739
Reference Allele:
G
-log10(P):
-361.005
MAF:
0.308
Beta (Num):
-0.023
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.388
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs7523082

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.138
Position:
151848126
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-10.497
Reference Allele:
T
-log10(P):
-57.684
MAF:
0.396
Beta (Num):
-0.124
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.014
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

This ratio likely reflects medium-chain fatty acid oxidation efficiency via ACADM, which catabolizes octanoylcarnitine's precursor; altered function impacts the denominator, shifting the ratio.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data