nonanoylcarnitine (c9) to myristoleoylcarnitine (c14:1)*

Numerator Metabolite

Structure of nonanoylcarnitine (c9)
Metabolite Accession: GCST90200031
Name: nonanoylcarnitine (c9)
Hmdb Id: HMDB0013288
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPSPNFAQQQMFLK

Denominator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Associated Genomic Regions

Region: rs4949674

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
-0.370
Position:
76213715
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-24.730
Reference Allele:
C
-log10(P):
-309.224
MAF:
0.302
Beta (Num):
-0.379
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.009
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid oxidation.5[1], 7[2], 8[3]

Ratio Explanation:

An increased C9/C14:1 ratio suggests reduced ACADM activity, causing upstream medium-chain acylcarnitine (C9) to accumulate relative to long-chain species (C14:1).9[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data is available; however, genetic variants that impair ACADM can lead to medium-chain acyl-CoA dehydrogenase deficiency (MCADD), affecting energy metabolism.1[1], 9[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data