(s)-3-hydroxybutyrylcarnitine to 3-hydroxydecanoate

Numerator Metabolite

Structure of (s)-3-hydroxybutyrylcarnitine
Metabolite Accession: GCST90200088
Name: (s)-3-hydroxybutyrylcarnitine
Hmdb Id: HMDB0013127
Super Pathway: NA
Sub Pathway: NA
Inchikey: UEFRDQSMQXDWTO

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs35630725;rs1890452

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.189
Position:
76192508
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
12.130
Reference Allele:
G
-log10(P):
-76.293
MAF:
0.337
Beta (Num):
0.151
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.038
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs56078223

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.269
Position:
151898843
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
16.481
Reference Allele:
T
-log10(P):
-138.849
MAF:
0.294
Beta (Num):
0.061
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.208
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Ketogenesis

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

Reduced ACADM function can lead to the accumulation of upstream metabolites like 3-hydroxydecanoate and altered levels of downstream products like (s)-3-hydroxybutyrylcarnitine, both involved in fatty acid oxidation.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered fatty acid oxidation due to genetic factors in ACADM may influence inflammatory processes or gut motility, potentially contributing to the development of diverticular disease, a condition also linked to genetics and diet.4[1], 5[2], 6[3], 7[4]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data