4-methylhexanoylglutamine to glutamine conjugate of c6h10o2 (2)*

Numerator Metabolite

Metabolite Accession: GCST90200223
Name: 4-methylhexanoylglutamine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs6593514

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.335
Position:
76203891
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-16.524
Reference Allele:
A
-log10(P):
-139.557
MAF:
0.308
Beta (Num):
-0.207
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.128
SE (Den):
0.015
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glutamine)

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glutamine)

Ratio Explanation:

The ratio likely reflects altered medium-chain fatty acid metabolism. A dysfunctional ACADM could lead to the accumulation of upstream fatty acid precursors, shunting them towards glutamine conjugation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data