tetradecadienoate (14:2)* to decanoylcarnitine (c10)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of decanoylcarnitine (c10)
Metabolite Accession: GCST90199722
Name: decanoylcarnitine (c10)
Hmdb Id: HMDB0000651
Super Pathway: NA
Sub Pathway: NA
Inchikey: LZOSYCMHQXPBFU

Associated Genomic Regions

Region: rs2185152

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.274
Position:
76224010
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
19.821
Reference Allele:
C
-log10(P):
-199.653
MAF:
0.309
Beta (Num):
-0.026
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.300
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs13320

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.135
Position:
151846517
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
-10.232
Reference Allele:
T
-log10(P):
-54.906
MAF:
0.395
Beta (Num):
-0.123
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.012
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio may reflect ACADM activity; a change could indicate altered beta-oxidation of medium-chain fats (decanoylcarnitine) relative to other available fatty acids (tetradecadienoate).4[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data