glutamine conjugate of c6h10o2 (1)* to decanoylcarnitine (c10)

Numerator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of decanoylcarnitine (c10)
Metabolite Accession: GCST90199722
Name: decanoylcarnitine (c10)
Hmdb Id: HMDB0000651
Super Pathway: NA
Sub Pathway: NA
Inchikey: LZOSYCMHQXPBFU

Associated Genomic Regions

Region: rs2185152

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.434
Position:
76224010
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
22.220
Reference Allele:
C
-log10(P):
-250.199
MAF:
0.311
Beta (Num):
0.134
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.300
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Omega-Oxidation, Amino Acid Conjugation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty Acid Beta-Oxidation.1[1], 5[2]

Ratio Explanation:

A high ratio of a C6 dicarboxylic acid-glutamine conjugate to decanoylcarnitine indicates impaired ACADM function, shunting fatty acids from beta-oxidation to alternative omega-oxidation pathways.6[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in ACADM impair fatty acid beta-oxidation, increasing decanoylcarnitine and redirecting metabolites to omega-oxidation, yielding the glutamine conjugate. No associated phenotype was provided.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data