3-hydroxydecanoylcarnitine to cis-4-decenoylcarnitine (c10:1)

Numerator Metabolite

Structure of 3-hydroxydecanoylcarnitine
Metabolite Accession: GCST90200246
Name: 3-hydroxydecanoylcarnitine
Hmdb Id: HMDB0061636
Super Pathway: NA
Sub Pathway: NA
Inchikey: VCRSQDIROUELAR

Denominator Metabolite

Structure of cis-4-decenoylcarnitine (c10:1)
Metabolite Accession: GCST90199880
Name: cis-4-decenoylcarnitine (c10:1)
Hmdb Id: HMDB0013205
Super Pathway: NA
Sub Pathway: NA
Inchikey: GOOOCIIXFLVRAG

Associated Genomic Regions

Region: rs61797339

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.372
Position:
76189946
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
27.023
Reference Allele:
G
-log10(P):
-368.645
MAF:
0.308
Beta (Num):
-0.019
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.391
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs17843929

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.187
Position:
159637113
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
12.654
Reference Allele:
C
-log10(P):
-82.828
MAF:
0.264
Beta (Num):
0.040
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.147
SE (Den):
0.017
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
PPID ETFDH C4orf46 FNIP2 RXFP1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

The ratio of 3-hydroxydecanoylcarnitine to cis-4-decenoylcarnitine reflects the activity of the ACADM enzyme in the mitochondrial beta-oxidation of medium-chain fatty acids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

A variant in the ACADM gene can lead to reduced enzyme activity, causing an altered ratio of 3-hydroxydecanoylcarnitine to cis-4-decenoylcarnitine, which are intermediates in fatty acid oxidation. However, no associated phenotype has been identified.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data